Breaking Down Patent Invalidation: Tactics, Forums, and High-Profile Cases

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1. Introduction

​In today’s fast-paced innovation landscape, patents play a critical role in securing competitive advantage. However, not all patents are bulletproof. Many face challenges from competitors, public interest groups, or defendants in infringement lawsuits. Patent invalidation serves as a vital legal tool to eliminate weak or overly broad patents, ensuring that only truly novel and non-obvious inventions enjoy protection. 

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2. Strategies for Invalidation: How Are Patents Challenged?

Given the legal frameworks above, those seeking to invalidate a patent (be it a defendant in a lawsuit, a competitor, or a public interest group) often employ a combination of strategies:

2.1 Prior Art Search and Analysis

The cornerstone of most invalidation efforts is a thorough prior art search. The goal is to find publications, patents, or products from before the patent’s filing that read on the claims. As one guide succinctly put it, “the primary goal of patent invalidation is to locate any prior art the USPTO examiner might have missed”​.

  • Armed with strong prior art, a challenger can argue lack of novelty or obviousness. This might involve not just well-known literature but also obscure manuals, university theses, or even old products (catalogs, Wayback Machine archives of websites for on-sale evidence).
  • In 2025, AI-driven search tools are increasingly used to uncover prior art including foreign language documents and even images (for instance, using image recognition to find similar diagrams that could invalidate a patent on a mechanical design).
  • A notable strategy is the crowd sourcing of prior art – platforms where interested communities or experts are invited to find prior art (the Linux Foundation and EFF have done this to bust patents they consider problematic).

2.2 Choosing the Forum

A challenger must decide whether to attack the patent in court or via a patent office proceeding (or both). Often, if sued for infringement in the U.S., a defendant will file an IPR petition at the PTAB as a parallel strategy, hoping the PTO will cancel the claims or at least put pressure on the patent owner.

  • If timing is an issue (e.g., you’re close to trial and Fintiv might block your IPR), you might stick to court. In Europe, one might file an EPO opposition if within the window, or use the UPC now for a broad revocation action.
  • The choice may depend on perceived advantages: the PTAB has technical judges and no jury, which can be good for complex patents, whereas a jury trial in court might be riskier for a challenger but allows arguments like inequitable conduct that PTAB would not consider.
  • Increasingly, challengers pursue multi-front attacks – for example, file an IPR to cover patentability issues and simultaneously argue other grounds (like lack of enablement or indefiniteness) in the court case.

2.3 Procedural Moves and Stays

When a post-grant review is instituted, challengers often move to stay the litigation, pausing the court case until the PTAB outcome. Courts in the U.S. frequently grant stays to conserve resources, especially if the PTAB is likely to simplify issues by invalidating some or all claims.

  • This can benefit challengers by delaying any potential injunction or damages and possibly mooting the case entirely if the patent dies.
  • On the flip side, patent owners sometimes try to avoid IPR by suing in venues or under timing that complicates the challenger’s ability to file (one tactic patent owners used was filing in the Eastern District of Texas and pushing a fast trial date to trigger Fintiv denials of IPR – although recent USPTO guidance has curtailed some of that).

2.4 Collaboration and Joint Defense

In cases where a patent is being asserted against multiple parties (like a so-called patent troll suing many tech companies on the same patent), those defendants often form a Joint Defense Group (JDG) to pool resources.

They might share the cost of prior art searches and jointly fund an IPR petition via one proxy filer. There are also third-party organizations like Unified Patents and RPX that specialize in filing IPRs to challenge patents that they see affecting their member companies.

Even outside defensive coalitions, we have seen non-profits join the fray: EFF famously crowdfunded and filed an IPR that successfully invalidated a broad podcasting patent which was used to sue podcasters​.

This case is a great example of a public interest-driven strategy: the goal was not to defend a specific defendant but to eliminate a patent that threatened an entire community of content creators. The PTAB’s processes allow such public challenges, and 2025 may see more activism in this area (for example, challenges to patents viewed as hindering access to COVID-related medical technology, etc.).

2.5 Expert Testimony and Trials

In court litigation, invalidation often comes down to a battle of experts, especially on questions of obviousness or whether a technical disclosure is enabling.

A challenger will bring in expert witnesses to explain how prior art renders the patent obvious, or how a person of skill would find the patent’s teaching insufficient.

In complex fields like pharmaceuticals, an expert’s testimony that a certain experiment would require undue effort can be decisive (as essentially happened in Amgen v. Sanofi).

Conversely, patent owners use experts to argue the art was not so straightforward. By 2025, given the number of precedents, expert reports also heavily engage with what past cases have held – effectively, experts discuss KSR guidelines, Wands factors (for enablement), etc., to frame their opinions in legally meaningful ways. This fusion of legal precedent and technical testimony is a hallmark of modern patent trials on validity.

2.6 Appeals and Persistence

Even if a challenger loses initially (say a patent is upheld in an IPR or at trial), the fight may not be over. Appeals to the Federal Circuit can and do overturn patent validity findings. The appellate court might find a patent should have been invalidated and reverse a lower court (or vice versa).

Some famous patents survived initial challenges only to be invalidated years later on appeal or in subsequent cases. Thus, a comprehensive invalidation strategy plans for the long game, including possible re-challenges. Notably, if one challenger fails, sometimes another challenger can try again (with different art or arguments), unless estoppel applies.

For instance, if an IPR is not instituted, other parties might still get a shot in their own petitions.

3. Case Studies: Patent Invalidation in Practice

To illustrate how these legal principles play out in real life, let’s look at a couple of concrete examples:

3.1 The Cholesterol Drug Patents (Amgen vs. Sanofi)

Amgen’s patents aimed to cover a groundbreaking class of cholesterol-lowering drugs (PCSK9 inhibitors). Amgen sued Sanofi for infringement, but Sanofi countered by arguing the patents were invalid for lack of enablement.

Through years of litigation, expert testimony showed that while Amgen’s patent claimed an entire genus of antibodies, it provided data for only a few and essentially told researchers to go experiment to find the rest – a “roadmap” or “trial-and-error” research assignment, rather than a true teaching.

The Supreme Court in 2023 agreed with Sanofi, emphasizing that a patent is not a reward for an idea alone, but for an actual teaching of how to practice that idea. The result invalidated Amgen’s patents, allowing Sanofi and others to freely market their competing antibody (Regeneron was Sanofi’s partner and co-defendant, and had also filed a revocation action in Europe). Interestingly, in Europe, the same underlying invention was challenged on a different ground – obviousness – and the newly formed UPC also invalidated the patent.

For Amgen, these losses were a significant setback, wiping out parts of their monopoly on a lucrative drug class. For the public, the invalidations ensured no single company could broadly claim all solutions to a problem without meeting strict disclosure or non-obviousness standards. This case study highlights how patent invalidation can impact high-stakes industries: patients, competitors, and investors all had something at stake in whether those patents stood or fell.

The European Patent Office in Munich. Europe’s patent system features an opposition process and the new Unified Patent Court, which in 2024 issued its first patent invalidation (revocation) decision. The global nature of patents means important inventions often face validity challenges in multiple jurisdictions simultaneously.

3.2 Battling a “Patent Troll” – EFF vs. Personal Audio

Personal Audio LLC was a classic non-practicing entity that claimed it had patented podcasting and went on to sue numerous content creators and media companies. The Electronic Frontier Foundation saw this as an abuse – the patent, they argued, was broad and shouldn’t have been granted.

  • In 2013, EFF raised funds from the public and filed an inter partes review petition against Personal Audio’s patent. They gathered prior art, including evidence of early RSS-based audio programs, and submitted expert declarations.
  • In 2015, the PTAB ruled in EFF’s favor, invalidating key claims of the so-called podcasting patent. This victory was celebrated by the podcast community, as it removed the looming threat of lawsuits over basic podcast technology. It’s a textbook example of how post-grant proceedings empower even small players or public interest groups to challenge a patent without the need for a full-blown court battle.

The success also demonstrated that sometimes the combination of community knowledge and the IPR process can unearth evidence the original examiners missed. After the patent was invalidated, Personal Audio’s lawsuits against podcasters crumbled. To many, this case study is a feel-good story of the patent system’s self-correction mechanism: a dubious patent was eliminated, innovation (in podcasting) was freed from a toll, and it didn’t require an expensive courtroom showdown.

3.3 VirnetX vs. Apple – A $576 Million Verdict Undone

VirnetX is a patent holding company that won a massive jury award against Apple over VPN and Facetime technologies. However, even as that court case was playing out, Apple was busy at the PTAB challenging VirnetX’s patents. Apple, through proxies and by joining others’ petitions, succeeded in getting the PTAB to invalidate the patents that underpinned the verdict.

In a dramatic turn, the Federal Circuit overturned the $576M judgment the day after affirming the PTAB’s invalidation of the patents. VirnetX cried foul at Apple’s tactics (using a hedge fund, Mangrove Partners, to file an IPR after Apple itself was time-barred, then joining that IPR) and took the issue to the Supreme Court.

While the High Court did not take the case, the episode underscores a key reality in 2025: a patent infringement win isn’t secure until the patent’s validity survives all challenges. Apple’s multi-front strategy – litigate, but also invalidate in parallel – paid off.

It also exposed a loophole (joining IPRs to escape time bars) which may or may not be addressed by future policy. For companies facing large damages or injunctions, this case study shows that fighting on the validity front can literally save hundreds of millions of dollars.

4. Expert Perspectives: Balancing Innovation and Invalidity

Patent invalidation sits at the intersection of innovation policy and law, so it’s no surprise that experts often disagree on whether the current balance is right:

4.1 Patent Holders’ Concerns

Many patent owners argue invalidation processes have become too aggressive, citing:

  • High PTAB invalidation rates (up to 70%)
  • Increased litigation costs and complexities
  • Fear that easy invalidation undermines R&D investment confidence

4.2 Public Interest & Challenger Viewpoint

Tech companies, non-profits, and public interest advocates highlight:

  • Need to eliminate weak patents that stifle competition and innovation
  • Importance of accessible post-grant reviews, like IPRs, to challenge overly broad claims
  • Success stories (e.g., EFF’s podcasting patent win) as examples of self-correction in the system

4.3 Judicial & Academic Views

Judges and scholars emphasize:

  • The role of invalidation in ensuring patent quality and fairness
  • Research showing that litigated patents with the weakest claims are often those invalidated
  • Ongoing discussions on harmonizing standards across jurisdictions

5. Conclusion

Patent invalidation remains crucial to maintaining a fair, innovation-driven marketplace. The legal strategies—ranging from thorough prior art searches and multi-front litigation to expert testimony and long-term appeals—ensure only deserving patents survive. While debates over the right balance continue, recent cases show invalidation processes are essential tools to prevent unjust monopolies and safeguard open innovation.

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